Investigating the relationship between serum and salivary levels of phosphorus and glucose in diabetics

Abstract

Introduction: The use of salivary compounds due to non-invasive has provided a suitable tool for the replacement of blood components. Due to the importance of phosphorus and glucose levels in many biological processes, this study evaluated the relation between serum and saliva levels of phosphorus and glucose in diabetecs patients referred to Tabriz Dentistry Faculty. Methods: This descriptive study was conducted on 40 patients referring to Tabriz Dental School. These patients were extracted according to standard protocols of serum and salivary. Data were presented mean (± standard deviation) and frequency (percentages) for quantitative and qualitative variable. To determine the correlation between serum and salivary levels of biomarkers was performed Pearson test by SPSS 24 software. The significance level of P <0.05 was considered. Results: From 40 subjects we studied were 23 women and 17 men. The average obtained for salivary phosphorus was (24.9 mg/dl) , which was higher than the average of serum phosphorus (4.6 mg/dl ),and on the contrary , and the average of salivary glucose was ( 4.4 mg/dl) ,which was less than the average serum glucose (128.6 mg/dl) .The result of paired samples T test ( p-value<0.05) showed that there is a statistically significant difference between the mean of serum phosphorus and salivary phosphorus,as well as between the serum glucose and salivary glucose. Pearson correlation test results showed that there is no significant correlation between serum phosphorus and salivary phosphorus (p-value>0.05), but there is a positive correlation between serum glucose and salivary glucose (p-value<0.001) The salivary phosphorus was higher than it in serum but it was the opposite about glucose. Conclusion: It is important to measure accurately the blood factors with the least damage to them. The study found that there was a statistical relationship between salivary glucose and blood of diabetics individuals. In the future, salivary samples can beused to measure glucose in these individuals.