Comparison of the effect of intravenous Midazolam with Dexmedetomidine infusion on sedation and duration of spinal anesthesia with Bupivacaine for cesarean section

Abstract

The aim of this study was to a comparison of the effect of intravenous Midazolam with Dexmedetomidine infusion on sedation and duration of spinal anesthesia with Bupivacaine for cesarean section. Materials and Methods: In this clinical trial study, 70 ASA I, II patients were randomly divided into two groups of 35. All patients received Bupivacaine for anesthesia. For the first group Dexmedetomidine (D) and for the second group, Midazolam (M), was infused. Then, the patients were compared in terms of pain score based on VAS score, duration of sensory block, sedation level and hemodynamic changes. Results: The mean pain severity was significantly higher in group M than in group D (p <0.001). The time interval before receiving the first analgesia was significantly higher in the group receiving Dexmedetomidine than the Midazolam group (p <0.001). In addition, the total analgesic dosage used in the postoperative period was significantly lower in group D (p <0.001). There was no significant difference in sedation score and hemodynamic variations between the two groups.