| dc.description.abstract | The aim of this study was to determine the serum concentrations of inflammatory (HsCRP ,PLA2) and oxidative (MDA, TAC, SOD) stress indices in relation to pain intensity and quality of life in patients with MPS compared to healthy controls.
Methods: The present study is a case-control study. The participants were selected from patients with MPS who referred to Tabriz specialized treatment health centers of Emam Reza and Shohada via convenient sampling, considering the inclusion and exclusion criteria. At the beginning of the study, the purpose and method of the study were described in detail for the participants and written informed consent was obtained from them. Demographic data were collected by face to face interview using general characteristics questionnaire. Visual analogue scale was used to assess pain intensity. The Quality of Life Assessment Tool was the Quality of Life Questionnaire (SF 36), which assesses quality of life in eight dimensions. Pressure pain threshold was evaluated by a pressure Algometer. Blood samples were collected by a laboratory expert to measure inflammatory and oxidative stress factors.
Results: Finally, 72 patients in the case group with a mean age of 37.43±9 9.10 years and 18 patients in the control group with a mean age of 34.22 ± 7.61 years were analyzed. According to the results, serum concentrations of hs-CRP, phospholipase A2 and oxidative stress index of malondialdehyde were significantly higher and serum concentrations of TAC and SOD antioxidant factors were significantly lower in the in participants with MPS compared with participants without MPS. Each unit increase in hs-CRP and malondialdehyde concentrations was associated with increased by 1.17 fold and 14.8 fold increase in the risk of MPS, respectively, after adjusting for age and body mass index (BMI). Total antioxidant capacity was associated with a protective effect against MPS after adjusting for age and BMI . All components and subscales of quality of life in case group were lower than control group. In the participants with MPS, resting pain had a significant positive association with serum concentrations of hs-CRP and phospholipase A2 and malondialdehyde oxidative and a significant inverse association with serum concentrations with antioxidant indexes of total antioxidant capacity and superoxide dismutase. Also, nocturnal pain had a significant positive association with serum hs-CRP concentration. | en_US |
