Evaluation of therapeutic effect of nimodipine on facial nerve injury following cerebellopeduncular angle tumor surgery

Abstract

The aim of the present study was to evaluate the effect of nimodipine on the malignant facial nerve malformation of the cerebellopeduncular angle tumor surgery. Materials and Methods: In this clinical trial study, patients with CPA tumors, those with pathologic vestibular schwannoma or meningioma with the largest diameter of 3 cm, who underwent bilateral facial surgery were excluded. The subjects underwent nimodipine 60mg daily every 6 hours after the first day of surgery. Follow up was first 3 and then 6 months after surgery. Weakness and pattern of recovery of facial nerve recovery as well as non-corneal improvement of facial and eyelid and eye condition of patients were evaluated and recorded based on House-Braekmann score. Results: In the evaluation of the results at the 3-month follow-up, there was a significant improvement; in the intervention group 17 patients (56.67%) were recovered from Grades II to IV to Grade I and II and 3 (10%) patients without improvement. They were also in Grades V and VI only one improvement from Grade VI to V was observed (p = 0.001). In the evaluation of the results at the 6-month follow-up, in the intervention group, 18 patients (60%) had improved from Grades II to IV to Grades I and II, and 3 patients (6.5%) had no improvement. They were. Also in Grades V and VI only one improvement from Grade VI to V was observed (p = 0.001). At both follow-up (3 and 6 months later); in the control group, only two cases of Grade II to IV had partial improvement and no improvement in Grades V and VI.