Clinical and Pathologic Features of Patients with Nonepithelial Malignant Ovarian Tumors at Gynecologic Oncology Division of Alzahra Teaching Hospital

Abstract

varian cancer is the second most common gynecologic cancer and the seventh most common cancer in women. Non-epithelial ovarian cancer includes germ cell and sex cord-stromal tumors. The incidence of this cancer appears to be related to socio-demographic and obstetric factors. The aim of this study was to investigate the relationship between these factors in nonepithelial ovarian tumors. Methods: The present study was performed on 30 patients with non-epithelial ovarian cancer in comparison with 100 controls, between 2011 and 2019. The patients were divided into two groups: germ cell tumor and sex cord-stromal tumor. Socio-demographic and obstetric charecteristics of patient and control groups were collected and recorded in a pre-designed checklist. Statistical analysis was accomplished by SPSS software (version 21.0). Results: The risk of germ cell tumor in patients with history of pregnancy was lower than the control group (p <0.01, OR = 0.182, 95% CI = 0.082-0.45). The mean number of pregnancies did not differ between Sex-cord and control groups (P = 0.62). The risk of germ cell tumor compared to the control group decreased by increasing number of full term deliveries (p <0.01, OR = 0.182, 95% CI = 0.135-0.672) but the number of full term deliveries had no effect on sex cord tumor (P = 0.056). The risk of developing germ cell tumor was higher in non oral contraceptives users than in the control group (OR = 7.24). The risk of germ cell tumor in patients without history of lactation was higher than in the control group (OR = 4.16). The risk of germ cell tumor (OR = 0.28) and sex cord tumor (OR = 0.07) decreased compared to control group with increasing age of menarche. The mean duration of ovulation in sex cord and germ cell tumors was higher than the control group (P <0.05).