Assessment of Serum COMP and Vitamin D levels and them accompany with disease activity in Osteoarthritis

Abstract

Aim: The aim of this study was to determine the levels of serum COMP and active vitamin D3 and its association with osteoarthritis activity. Materials and Methods: Sixty patients with a diagnosis of osteoarthritis were entered in the study. Before the start of the study, clinical criteria of patients based on WOMAC scoring system were evaluated by a specialist physician. Control subjects were also selected based on the rejection of the disease based on clinical examinations and if necessary, routine tests. After selecting patients and control subjects, blood samples were taken from each patient after 12 hours fasting and the sera were frozen after isolation at -70 ° C until completion of the samples. After completing the samples, the serum level of COMP was studied.. Results Of patients with osteoarthritis, 13 cases (21.7%) were males and 47 (78.3%) were females. Of the patients in the control group, 12 cases (40%) were male and 18 (60%) were female. Mean ± standard deviation of patients with osteoarthritis group age was 57.67 ± 10.63 years. Mean ± standard deviation of control group age was 56.03 ± 5.78 years. Mean ± standard deviation of serum COMP level in patients with osteoarthritis was 40.82 ± 10.44 ng / ml and 26.71 ± 9.39 ng / ml in the control group. Correlation of COMP with disease activity (WOMAC) was statistically significant (p = 0.018). Correlation of COMP with changes in degrees of osteoarthritis was observed in the patients (p = 0.004). In the correlation between the disease activity (WOMAC) and degree of osteoarthritis in the patients, there was a significant and inverse correlation (p = 0.001). In assessing the COMP's diagnostic value in osteoarthritis, the AUC was 0.836 (p = 0.001, r = 0.043 and 0.91-0.951 CI = 951 751/0).