The effects of diet enriched with indigestible/fermentable complex carbohydrates on intestinal microbiota of chronic hemodialysis patients

Abstract

The purpose of this study was to evaluate the efficacy of digestive-resistant starch in correcting and altering gastrointestinal flora in end-stage renal disease patients under chronic hemodialysis.Materials and Methods: In this double-blind clinical trial, 20 hemodialysis patients were selected from patients referred to Tabriz University of Medical Sciences' clinics. These patients were randomly divided into control and treatment groups. Patients in the treatment group received daily 25 grams of amylose-rich starch for 2 months and were finally compared for quantitative microbial comunity analysis.Results: The control group showed only statistically significant changes in Prevotella and Faecalibacterium genus. There was a statistically significant increase in the two genotypes in this group. There was a statistically significant difference in the Bacteroides genotype in the intervention group in the reduction of colonies