Association between serum vitamin D level and Spondyloarthropathies disease activity

Abstract

This study aimed to compare serum vitamin D levels in Spondyloarthritis (SpA) patients and control group and to evaluate the associations between vitamin D and disease activity in SpA patients.

Methodology: In this study, 86 SpA patients according to the International Criteria and 117 age and sex-matched healthy controls were included. In patients, clinical examination was performed and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were recorded. Serum 25(OH)D3 concentration was measured using ELISA kit.

Results: Serum 25(OH)D3 levels in SpA patients were significantly lower than healthy controls (p<0.001). Vitamin D deficiency and insufficiency frequency in the SpA group was significantly more than control group (p<0.001). No significant difference was observed in the activity of SpA in different serum levels of 25(OH)D. Also, no significant correlations were observed between serum 25(OH)D3 with clinical findings as well as with BASDAI and BASFI (P>0.05).