The effect of glucosamine on intestinal permeability of beta-blockers

Abstract

Glucosamine has been widely used these days to enhance the quality of life in patients with osteoarthritis because of its positive effects on the retention and strength of connective tissue as well as the analgesic and anti-inflammatory effects. Beta-blockers comprise a wide range of drugs that are commonly used in the treatment of different cardiovascular diseases. The effect of glucosamine on the intestinal absorption of beta-blockers was investigated in this study. Objective: The aim of this study was to investigate the effect of glucosamine on intestinal absorption of propranolol and atenolol. Materials and Methods: Constant concentrations of propranolol and atenolol were obtained and combined with different concentrations of glucosamine. Each of these solutions was perfused in three rats by SPIP method for 60 minutes and samples were taken at specified time intervals from the output solution from the intestine. The samples were analyzed by HPLC and the results were analyzed by ANOVA test. Results: In the both studied groups, in the second, third and fourth groups containing 100, 500 and 1000 μg/mL of glucosamine, respectively, effective intestinal permeability was increased compared to the first group (control group), which did not had glucosamine. In the fifth group of the experiment, containing 5000 μg/mL glucosamine, the effective intestinal permeability of propranolol and atenolol decreased compared to the control group, all of which were significant. Conclusion : Glucosamine changes the intestinal absorption levels of some drugs, including beta-blockers, which can disrupt the treatment process and may require a specific dose adjustment for the patient.