Effect of injectable Betamethasone for fetal lung maturation on glycemic control

Abstract

Preterm labor is an unresolved problem that accounts for 10-5% of pregnancies and is widely associated with motility and neonatal morbidity. Prescribing glucocorticoids in pregnant women at risk for early delivery is one of the most important and effective treatments used to improve neonatal pulmonary function and reduce neonatal mortality. Concomitant administration of these drugs can lead to maternal hyperglycaemia, especially in cases (GDM) or diabetes. Materials and Methods: In this study, 141 pregnant women admitted to Tabriz Alzahra Hospital during the first half of 2018 were treated with betamethasone 12 mg muscle at the first dose and 12 mg muscle 24 hours after the first dose. Were studied. In this population, patients who had previously had a normal blood glucose screening test were compared with patients with GDM-controlled diets and patients with insulin-dependent GDM and patients with insulin-dependent diabetes insights. In these patients, fasting blood glucose, glucose was measured one hour after breakfast, lunch and dinner on the first day of betamethasone administration, and on the second, third and seventh day after the first dose of betamethasone with a zero and one glucometer. Results: The results of this study showed that beta-methasone injection in all groups increased the mean FBS and the highest increase was observed after the second dose, the second day. Also, the results of the study showed that the blood sugar level of 1 hour (hpp1) after breakfast, lunch and dinner in the four groups after the second day after betamethasone injection was higher than other days, and this difference was observed in the GDM and diabetic subjects with treatment Insulin was significant between the first and second days (P <0.05). The need for insulin injection was a downward pathway after betamethasone injections, and over time, the need for insulin was reduced and close to pre-betamethasone levels.