| dc.description.abstract | Methotrexate is an antifolate chemotherapeutic agent that has been widely used in the treatment of Malignancies, Auto-Immune, and other Non-Malignant diseases. High Dose Methotrexate (HDMTX), defined as a dose higher than 500mg/m2 is used in Malignancies treatment. Regarding to over usage, Methotrexate is a drug causes the liver injuries. The most acute of them is Cirrhosis. According to the wide studying subjects, a similar studying has not been studied the effect of MTX in the zone. Thus, we decided to study the evaluation of high dose methotrexate hepatotoxic effects 10 years after treatment of malignancy in children.
Methods: In this Cross‐sectional Study, the liver side effects of Methotrexate with a high dose in 30 patients affected by hematologic malignancies (ALL, NHL) , hospitalizing in Tabriz children hospital, were being studied between 2008-2010. The level of aminotransferases, the liver function tests, liver and bile duct sonography and Color doppler sonography of portal system were done in all the patients. The diagnosing methods of produced data, and the patients demographic information were collected in a questionnaire. And, at last, The data after categorization entered to SPSS software, and appropriate statistical analysis was done.
Results: There were 30 patients whom being studied, 18 of them, or 60 % were the boys , and 12, or 40% were the girls. 23 of the cases or, 76.67% affected with ALL and 7 patients, 23.23% affected with NHL. In the lab findings, ALT level had been increasing in 4 cases, or 13.23%. The Total BILL serum in 4 cases, or 13.23% and Direct BILL in 3 cases or 10% were above the normal level. The AST serum level , PT and PTT were in normal ranges in all the patients. In patients’ sonography findings, the liver Span in 8 cases, or 16.67%, and the spleen Span in 12 cases, or 40% were larger than normal size. The echogenicity of the liver had been increasing mildly in 5 patients, 16.67%, and there were the evidences of fatty liver changes in them. The portal vein diameter in all patients was normal and there were no evidence of thrombosis in them. | en_US |
