Effect of antiseptic and antibiotic usage within the implant on the proinflammatory cytokines interleukin 1β and interleukin 6 in GCF for the contact of the implant and abutment

Abstract

Introduction: The control of diseases around the implant is difficult and unpredictable. Pre-inflammatory cytokines in the fluid in the groove surrounding the implant indicate the condition of the disease or the health surrounding the implant. The aim of this study was to investigate the effect of four substances of chlorhexidine, tetracycline, saliva and dry environment on the level of IL-1β and IL-6 interleukin-II pre-inflammatory cytokines in the gingival fluid of the implant and abutment contact point. Materials and methods: In this Clinical Trial study, patients referring to the private office of two prosthodontists who were seeking implants, split mouth were studied. Osstem unit implant system was used in each patient. In each of the implants, 4 different substances (chlorhexidine 2%, tetracycline 3%, saliva and dry environments) were used. Each of the materials examined was placed inside the ankovering session inside the implant bolt and the healing screw was closed. Then, in three sessions of denture delivery, one month after the delivery of the prosthesis, the patients were sampled. For gingival fluid sampling after oral cleansing (half an hour after 3 minutes of complete brushing). Data were analyzed by SPSS software, ANOVA and post hoc monitoring.

Results: Results showed that 58.3% (14 cases) were female and 41.7% (10 persons) were male. Significant differences were observed between mean IL6 and IL1β in four types of substance (p <.05). IL6 IL1β was similar in tetracycline and chlorhexidine, but significantly higher than saliva and dry media (p <.05). IL6 and IL1β levels in saliva were significantly higher than the dry medium (p <.05). Conclusion: Using tetracycline at the site of the implant and abutment contacts reduces the IL6 IL1β inflammatory cytokines.