Assessment of Serum levels of CXCL10 and vitamin D and their correlation with severity of renal involvement and disease activity in patients with lupus nephritis

Abstract

The evaluation of CXCL10 and vitamin D markers in some of the disorders mentioned have been considered. However, the assessment of these markers in the autoimmune lupus is less relevant and it seems that these markers, especially in lupus nephritis, are due to kidney involvement and also active immune system has significant changes. ThereforeThe aim of the present study was to investigate CXCL10 and vitamin D in patients with lupus nephritis, so that one of the most important challenges in assessing the disease activity of Lupus Nephritis was achieved, which certainly affected the subsequent therapies. Methods: In this case-control study, 30 lupus patients with lupus nephritis were diagnosed by nephrologists based on SLICC criteria and 30 controls were matched for age and sex with the patient group. Then, all blood samples were taken for the tests necessary for the examination of CBC, Cr, UA, Anti Ds DNA, ANA; C3, C4, 24 urine protein was taken from patients and the disease activity criteria were measured based on SLEDAI. Also, all renal biopsy patients were evaluated for classification and renal activity index. In this study, ELISA technique was used to measure CXCL10 and Vit-D levels. Finally, SPSS-23 software was used to analyze the data. Results: The results of our study indicated that the levels of CXCL10 and proteinurin in the group of lupus nephritis were higher than the two groups of lupus and healthy subjects. While the amount of vitamin D in the lupus nephritis group was lower than that of the control and lupus groups. Mean comparison indicated indices among the different groups showed that there was a significant difference between the mean value of CXCL10 and the amount of Proteinurin in the two groups of lupus and lupus nephritis, while vitamin D was between the two groups of lupus and There was no statistically significant difference in lupus nephritis. Also, the results indicated that there was a statistically significant difference between the mean of vitamin D in the control and lupus groups, while there was no statistically significant difference between the control and lupus CXCL10 indices and age Cannot be seen. Finally, the comparison of mean values of CXCL10 and vitamin D showed that there was a significant difference between the two groups in control and lupus nephritis.