The effect of intravenous selenium on oxidative stress in ARDS patients in intensive care units

Abstract

Acute respiratory distress syndrome (ARDS) is a clinical syndrome with distinct etiologies. Though tissue injury mechanisms have not been fully elucidated yet, there are evidence showing oxidative injuries due to reactive oxygen species (ROS) and anti-oxidant therapies have been suggested as a treatment plan. Taking into account that no study has evaluated the effects of intravenous Selenium on oxidative stress in ARDS patients, we decided to evaluate it. Methods: this study was conducted as a clinical trial and amongst admitted patients with the diagnosis of ARDS to Imam Reza hospital (from May 2016 to May 2017), 20 cases were selected, randomly and were divided into two groups. Both groups were treated with routine treatments of ARDS; while, the case group received intravenous Selenium and control group received placebo. The results of treatment were studied in two groups. Results: IV Selenium had no statistically significant effects on reducing oxidative stress, mechanical ventilation period, admission duration, the vasopressor treatment period and mortality in ARDS patients, in comparison to placebo group.