| dc.description.abstract | Introduction:
Obesity is a multifactorial disease, caused by an imbalance between energy intake
and energy expenditure. Obesity is considered as a risk factor for many chronic
diseases. Several hormones are secreted from various tissues of the body as well as
from the adipose tissue that influence the metabolism of adipose tissue and play a
role in pathophysiology, prevention and management of obesity. Nowadays, the
importance of irisin, betatrophin and lipocalin-2 in termogenesis, proliferation of
pancreatic beta cells, insulin secretion and inflammatory processes have been
reported. Considering the high prevalence of obesity and the importance of
hormones and the limited evidence, the aim of this study was to compare the serum
levels of these factors in normal and obese groups and their relation with
anthropometric indices and lipid and glucose factors.
Methods:
In the present descriptive-analytical research, 90 male and female participants aging
20-55 years were included in 2 groups with normal BMI and grade-1 obesity (n=45
each grops). The groups were matched based on sex and gender. Weight, height,
waist and hip circumference, serum levels of irisin, betatrophin and lipocalin-2,
lipid profile and blood sugar were measured in participants. Then BMI, abdominal
indices and atherogenic indices were calculated. Physical activity was measured via
International Physical Activity Questionnaire (short form) and Food intake was
measured via a Food Frequency Questionnaire and the data were analyzed using
SPSS (version 24) software.
Results:
In this study, serum levels of irisin and betatrophin were significantly (P <0.005)
higher in the normal group, whereas serum levels of lipocalin-2 in obese group were
significantly (P <0.005) more than normal group. In the whole population, there
was a significant and inverse correlation between serum irisin and anthropometric
indices, triglyceride, total cholesterol (TC), total energy and macronutrient intake.In case of betatrophin, there was a significant and inverse correlation between
betatrophin serum levels and anthropometric indices, TC, total energy and fat
intake. However, contrary to these two factors, there was a positive and significant
correlation between serum lipocalin-2 levels and anthropometric indices,
triglyceride, total energy and macronutrient intake. No significant association was
observed between serum levels of irisin, betatrophin and lipocalin-2 and fasting
blood sugar.
Conclusion:
In conclusion, serum levels of irisin, betatrophin and lipocalin-2 were significantly
different between groups and had a significant relationship with some
anthropometric and biochemical indices. However, further studies on the role of
these factors in the pathophysiology of obesity and its treatment are necessary. | en_US |
