Introduction Uric acid is a metabolite of purine nucleotides. Uric acid is a strong reducing agent and one of the main antioxidants in plasma, Due to its low solubility in aqueous solution, it may accumulate in the human ...

Background: Active targeting strategy in chemotherapy drug delivery aims to improve the therapeutic outcomes and minimize the side effects of chemotherapeutics. The epidermal growth factor receptor (EGFR) is a promising ...

Introduction: Increased gene expression of P-glycoprotein in the blood-brain barrier is one of the reasons for tolerance to the analgesic effects of morphine. It is possible that the drug clarithromycin causes inhibition ...

Background and Objective: A precise observation is that the cervix’s solid tumors possess hypoxic regions where the oxygen concentration drops below 1.5%. Hypoxia negatively impacts the host's immune system and significantly ...

Introduction: Nowadays, research in the field of new drugs obtained from natural sources has become important as a way of strategic value [1]. Modern lifestyle, improper use of antibiotics, etc., by disrupting the microbial ...

Introduction: Nowadays, most of the disease are diagnosed by medical imaging methods. Most imaging is done by using special drugs, we called radiopaque contrast agents.Contrast media are groups of chemical agents developed ...

Oxidative stress is recognized as one of the important factors in the occurrence and progression of cancer. In recent years, the unique antioxidant activity of grape seed extract has compelled researchers to evaluate its ...

مقدمه: سیلیبینین نوعی دارو با منشا گیاهی و اثرات ضدسرطانی و محافظت کنندگی کبد است که به دلیل ساختار هیدروفوب خود و محلولیت کم، کاربرد محدودی در بالین دارد به همین علت است که از هیدروژل‌ کیتوزان-دی‌آلدهید استارچ استفاده ...

Introduction:Several mechanisms (increasing NMDA receptors, increasing p-gp gene expression, etc.) are involved in the tolerance to the analgesic effects of morphine. Dextromethorphan is an antitussive and a p-gp substrate. ...

Introduction: Several mechanisms have been proposed in neuropathy caused by the use of anticancer drugs, including oxidative stress, increased activity of NMDA receptors and serotonin receptors. Bee pollen has anti-inflammatory ...