Preparation of Tadalafil-nanoemulsion with PIT method for topical drug delivery intended to be used in the treatment of androgenic

Abstract

Alopecia is a common dermatological disorder. The proposed drug,Tadalafil, with a mechanism of action that inhibits the breakdown of cGMP by PDE5 can prolong smooth muscle relaxation and increasing blood flow, and works as a minoxidil. Nanoemulsions are products with high stability against sedimentaion and creaming. There are various techniques to produce nanoemulsions. The proposed method is the PIT method, which is low-energy method and has been considered for cost reduction. Aim: The recent study was conducted for preparation of Tadalafil-nanoemulsion by the PIT method and effects of the different factors involved in the preparation of the formulations for topical drug delivery. Method: Tadalafil-nanoemulsions were prepared by PIT method, and the effects of change in NaCl and surfactant concentrations on stability, phase inversion temperature and particles size were investigated. Conductivity and particles size was also recorded.

Results: The ionic strength has had an effective impact on the formation of stable nanoemulsions and their particle size. Increasing NaCl concentration from 0.1 to 0.4 M reduced the particle size from 113 nm to 87 nm. Stability of nanoemulsions in 0, 0.05 and 0.1M were higher than their higher concentrations. By increasing the SOR factor that associated with the concentration of surfactant, from 0.2 to 0.4, the particle size decreased from 242 nm to 113 nm . Increase heating-cooling cycles up to 4 times, reduced particle size from 457 to 399 nm.

Conclusion: Nanoemulsions have been prepared using the PIT emulsification method for an oil/ nonionic surfactant/ water system. This study investigates the effects of NaCl, SOR on HLB temperature. Electrical conductivity as an important indicator of PIT and particle size were measured. It provides some useful insights into the formation of nanoemulsions that can be used as delivery systems for various industrial applications.