The effect of Tripterygium wilfordii roots supplementation on the metabolic status, anthropometric indices and serum levels of leptin and Chemerin obese women

Abstract

Background: Obesity is a chronic disease characterized by a disorder in body composition and expressed as a relative or absolute increase in body fat content. Obesity is associated with several complications, including high blood pressure, diabetes, heart attacks and brain and diabetes. Natural plants and natural products have a special place in the treatment of obesity. Researchers and scientists have been very interested in these products. T. wilfordii is one of the most prominent examples of its anti-obesity effects. Therefore, this clinical trial study was conducted to investigate the effect of 200 milligrams of T. wilfordii roots on the metabolic status, anthropometric indices and serum leptin and chemerin levels in obese women. Material and Methods: This double-blind clinical trial was conducted on 40 obese women referred to obesity clinic and Kermanshah Diet. Individuals were randomly assigned to two groups (intervention and placebo). Individuals consumed one 200 mg tablet daily with lunch. At the end of the eighth week, 5 cc blood was taken (after 8-12 hours of fasting). Fasting blood was used to test insulin, glucose, lipid profiles, chemerin and leptin. After about half an hour after bleeding, the serum samples were separated. General characteristics questionnaire, anthropometric indices, IPAQ Physical Activity Questionnaire and Appetite Level Questionnaire were completed 24-hours a day at the beginning of the intervention and at the eighth week by the participants. Results: At the end of the study and after 12 weeks, a significant decrease in weight and BMI was observed (P> 0.05). Also, there was a significant decrease in total cholesterol, fasting blood glucose, insulin and insulin resistance (P value> 0.05). There was also a significant decrease in serum leptin levels. However, no significant changes in serum levels of triglycerides, LDL, and HDL were found (P-value <0.05). Also, no significant difference was found in terms of low cholesterol levels (P <0.05). Conclusion: After a-12 week of intervention with the roots of T. wilfordii, significant changes were found in terms of weight, BMI, total cholesterol, fasting blood sugar, insulin, insulin resistance, and serum leptin levels. No significant changes were found for triglyceride, LDL, HDL, and chemerin.