| dc.contributor.advisor | Shirmohamad, Masoud | |
| dc.contributor.advisor | Taher Eftekhar-Sada, Amir | |
| dc.contributor.author | Sadeghi, Mohammad Reza | |
| dc.date.accessioned | 2019-01-23T05:46:28Z | |
| dc.date.available | 2019-01-23T05:46:28Z | |
| dc.date.issued | 2019 | en_US |
| dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/59659 | |
| dc.description.abstract | While expression levels of Nrf2 and ABCB1 (P−gp) were markedly higher in both mRNA and protein levels in CRC biopsies (p < 0.01), Keap1 expression level was significantly lower in these samples (p < 0.05). Positive correlations between Nrf2 expression level and tumor size (p = 0.003), lymph node (p = 0.038), distant metastasis (p = 0.008), and smoking status (p = 0.02) were observed. However, P–gp expression was associated only with patient age and smoking status. In addition, there was a positive correlation between protein levels of Nrf2 and P−gp, in both CRC (r = 0.617, p < 0.001) and non−CRC tissues (r = 0.930, p < 0.001). | en_US |
| dc.language.iso | fa | en_US |
| dc.publisher | Tabriz University of Medical Sciences Faculty of Advanced Medical Science | en_US |
| dc.relation.isversionof | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/59658 | en_US |
| dc.subject | ABCB1/P−gp Chemotherapy Clinicopathological criteria Colorectal cancer Keap1 Nrf2 | en_US |
| dc.title | Evaluation of Nrf2 signaling pathway in biopsy specimens of patients with colorectal cancer | en_US |
| dc.type | Thesis | en_US |
| dc.contributor.supervisor | Samadi, Nasser | |
| dc.contributor.supervisor | Somi, Mohammad Hossein | |
| dc.identifier.docno | 165 | en_US |
| dc.contributor.department | Moloucular Medicine | en_US |
| dc.description.discipline | Moloucular Medicine | en_US |
| dc.description.degree | Ph.D | en_US |
