Investigation of naproxen pellets bioavailability in rat model

Abstract

Introduction: Naproxen is a non-steroidal anti-inflammatory drug (NSAID). It is widely used to relieve pain in many diseases. The usual form of drug is the pill market and capsule. These drugs are used to reduce inflammation and pain and fever because they are able to inhibit the cyclooxygenase enzyme (COX1-COX2), both of which produce prostaglandin. . . . . . . . . . . . . . . . . . Aim: The purpose of this study was to evaluate the bioavailability of pellets containing naproxen in rat model. . . . . . . . . . Materials and Methods: Wistar male rats were randomly assigned to four groups in a weighing range of 220-260 g. The study groups included E formulation, M formulation, LS14 formulation, LS17 formulation, and conventional pill (control group (C)). Microcapsule pellets and normal naproxen were gavage to groups. After sample preparation, each sample was analyzed by HPLC. In this study, extraction methods with tertiary butyl ether, diethyl ether, di-chloromethane, normal hexane and chloroform solvents were used which ultimately yielded the best result with chloroform solvent. . . . . . . . . . . Results: The results of this study indicate that formulations of naproxen pellets are more effective in terms of bioavailability and drug concentration in plasma. Conclusion: By comparing the types of naproxen pellets in terms of bioavailability and concentration of drug in plasma, with its usual form, it can be seen that their distribution is better in the body. . . . . . . . . .