Investigating the effect of alkaline amino acids on the solubility of Ibuprofen

Abstract

Introduction: The development of a meaningful dissolution procedure for drug products with limited water solubility has been a challenge to both the pharmaceutical industry and the regulatory bodies. In the present study a dissolution medium was developed for Ibuprofen which is a class ӀӀ BCS and non-steroidal anti-inflammatory drug (NSAID) that is widely used for the treatment of medium pains,fever and inflammation. Aim : The aim of this study was to evaluate the effects of alkaline amino acids on Ibuprofen solubility. Material and methods : Solubility of Ibuprofen in different concentrations of Arginine- Lysine alkaline amino acids and Glucosamine, included in environments of phosphate buffer with pH = 7/4, sodium chloride solution with pH = 1/2, citrate buffer with pH = 6 and water with pH = 6/5 was studied. To measure the solubility of Ibuprofen in different dissolution environment, the classic method of saturation shake-flask was used. Results : Based on the obtained data, Arginine amino acid had a greater role in increasing the Ibuprofen solubility to lysine. The highest solubility of the drug can be seen in media consisting less concentration of Glucosamine along with citrate buffer. In fact, Glucosamine at lower concentration had a greater role than Arginine in solubility of Ibuprofen.

Discussion and conclusion : To increase the solubility of the Ibuprofen in environment containing water, phosphate buffer and sodium chloride solution, we need much concentration of Arginine and Lysine amino acids. While Glucosamine increases the amount of solubility more than two other amino acids. Based on the obtained data, we might say that the most suitable environment to increase the solubility of Ibuprofen was one which contains citrate buffer along with Glucosamine.