| dc.contributor.author | hamzezade, Arezoo | |
| dc.date.accessioned | 2019-01-14T09:49:15Z | |
| dc.date.available | 2019-01-14T09:49:15Z | |
| dc.date.issued | 2018 | en_US |
| dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/59595 | |
| dc.description.abstract | In this thesis, we investigated the expression of miR-155 and miR-181b in uterus and effect of Genistein on expression of these two miRNAs in ovariectomized rats.
Materials and methods: 40 female Wistar rats in weight range of 180- 220 were divided into 4 groups of control, Sham, ovariectomized (OVX) and ovariectomized+ Genistein treatment (OVX+ G) accidentally. Genistein was administered with a dose of 1 mg/Kg/dayfor8 weekssubcutaneusly.Effects of this intervention on expression of miR-155 and miR-181b were studied by Real-Time PCR method.
Results: Ovariectomy increased miR-155 expression and decreased miR-181b expression in uterus of rats (p< 0.05). Genistein down- regulatedmiR-155 expression and up- regulated miR-181b expression in uterus of ovariectomized rats (p<0.05). | en_US |
| dc.language.iso | fa | en_US |
| dc.publisher | Tabriz University of Medical Sciences, Faculty of Medicine | en_US |
| dc.subject | ovariectomy | en_US |
| dc.subject | Genistein | en_US |
| dc.subject | miR-155 and miR-181b | en_US |
| dc.title | Effect of genistein on expression of miR-155 and miR-181b in the uterus of ovariectomized rats | en_US |
| dc.type | Thesis | en_US |
| dc.contributor.supervisor | Ahmadiasl, Nasser | |
| dc.contributor.supervisor | Alihemmati, Alireza | |
| dc.identifier.docno | 608914 | en_US |
| dc.identifier.callno | 8914 | en_US |
| dc.description.discipline | Physiology | en_US |
| dc.description.degree | M.Sc | en_US |
