The Relationship between the Level of Serum S100B and GFAP Biomarkers with Mild Traumatic Brain Injury

Abstract

Mild traumatic brain injuries (mTBI) affect millions people each year. In acute settings diagnosis of mTBI is based on neurological examinations and imaging tools such as CT scan and MRI. Hower CT scans has a low sensitivity to diffuse brain injuries and exposes people to radiation. Despite validated decision making rules, it alongs excesive costs such as overtriage to CT scans. The usefulness of S100B and GFAP has been noted as a biomarker in the management of mildtraumatic brain injury (mTBI) in adults. Methods:41 Adult patients with mild TBI (GCS 14-15, loss of consciousness and/or amnesia), included in this study. Included patients completed the required CT scan as part of routine care and had blood drawn for analysis within 6h of injury. In control group we included 40 patients with simple exterimity fracturs, and blood sample was drawn in 6h after injuries. Results: results had showen that mTBI has correlated with higher level of S100b and GFAP in contrast with orthopedic injuries (P-value=0.01). In mTBI group S100B had 82.9% specifity for cutoff=100ng/l and for GFAP 0.00% specifity. GFAP in cutoff=6000 ng/l had 85% specifity. In control group the same result has been achieved.