Association of Colonization of the respiratory tract with Urea plasma urealyticum and Bronchopulmonary Dysplasia in very low birth weight newborns

Abstract

The aim of the present study was to investigate the relationship between colonization of respiratory tract with Ureaplasma urealyticum and contracting Bronchopulmonary dysplasia. Materials and Methods: This prospective cohort study was conducted in 2017 in the neonatal intensive care unit of Alzahra Hospital in Tabriz. The samples included newborns weighing less than 1500 grams and with gestational age less than 32 weeks whom required intubation within 72 hours after birth for any reason. After recording the initial information, the secretions within the trachea were aspirated and by PCR methodexistence of Ureaplasma Urealyticum was detected in refrence laboratory.Afterwards,we investigate BPD at the age of 28 dayafter brith. In order to analyze the data, SPSS software version 22 and descriptive-analytical statistics were applied. Findings: Among 82 newborns with inclusion criteria, 21 cases (26.3%) were excluded from the study due to dispatch or death before the age of 28 days. Among the rest (61 newborns), 3 cases (4.3%) included secretions infected with Ureaplasma and 33 cases (54.1%) suffered from Bronchopulmonary dysplasia. All three newborns infected with Ureaplasma infection contracted Bronchopulmonary dysplasia; however, no significant relationship between Ureaplasma infection and contracting BPD was observed (P=0.24). According to the data analysis, the most important factor of contracting BPD among the studied patients were the gestational age and birth weight; in other words, for each week increase in the age of pregnancy and for each 100-gram increase in birth weight, the likelihood of contracting BPD is reduced by 55% and 1% respectively.