Comparing the effects of high dose and low dose corticosteroids in breast granulomatous mastitis and fistulisation, A Cross Sectional

Abstract

Granulomatous mastitis is a rare secondary complication of a great variety of other Granulomatous disease with similar clinical symptoms. This might lead to a misdiagnosis and delayed treatment plan costing the patient and the therapeutic system. Method and Materials: This research is cross-sectional study designed to determine the effect of high and low dose corticosteroid therapy on patients returned with pain, swelling or mass, to the Tabriz University of Medical Science clinic and Imam Reza hospital in Tabriz, since April 2016 to April 2018. Results: The results of this study were based on data of 30 extracted cases with diagnosis of Granulomatous mastitis, 15 patients teated with low dose corticosteroid and 15 patients teated with high dose corticosteroid. The case study contains checklists and information from thirty patients that were chosen according to the input/output criteria. All of the patient were female with the age range of 21 to 47 and the mean age of 32.8±1.36. Majority of the patients complained about pain and feeling mass, discharge, inflation or any combination of them. None of the cases have had any of the systemic diseases or any specific Granulomatous or breast related issues in record. None of them were a contraceptive agents user. All the cases were within their fertile age with on average two children. Although all the serologic and bacterial tests returned negative. 2 cases had to be subjected to abscess drainage due to the nonstop discharge and multiple abscesses. All the patients prescribed 2 months of steroid treatment. They were put into two groups for high and low dose treatment plans and assigned a followup for the feedback. The plan was extended up to 1 year for the cases who were not cured by the original period and all remediated. All the cases were studied through sonography over time and the curing sings were recorded. There was a reasonable correlation between high dose of corticosteroid therapy and full treatment of the patients.( p-value < 0.01)