evaluation of miR-195 expression level in blood samples of patients with DVT

Abstract

Deep vein thrombosis is one of the most common cardiovascular diseases caused by the formation of a clot in deep veins. DVT is a complex disorder and a number of causes whose clinical manifestations are initially asymptomatic and this fact has led to its clinical significance being ignored due to the prevalence of venous thrombosis and the lack of easy methods for identifying people at risk for this condition. The high level of identification of some high bio-markers in this group of patients is felt today. The use of MicroRNAs as diagnostic biomarkers through blood and human plasma monitoring makes it possible to detect human diseases without any invasive methods. In this regard, in the present study, changes in the relative expression of miR-195 in patients with deep vein thrombosis were evaluated. method This study was performed on 40 patients with VDT and 40 healthy subjects selected after gender and age matched as control group. The relative expression of miR-195 was measured using PCR findings: The relative expression level of miR-195 in the case group was significantly increased compared to the control group

Conclusion: Our findings showed that the relative expression of miR-195 gene could be used as a diagnostic or predictive biomarker in DVT