Two bioactive ferulic acid derivatives from Eremostachys glabra

Abstract

Two ferulic acid derivatives, hexacosyl-(E)-ferulate [1] and leucosceptoside A [2], have been isolated from the rhizomes of Eremostachys glabra. The chemical structures of these compounds have been elucidated by UV, ESIMS, 1H NMR and 13C NMR spectroscopic analyses, and also by comparing experimental data with respective literature data. The free radical scavenging activity and general toxicity of these compounds have been assessed. While none of these compounds has shown any significant general toxicity in the brine shrimp lethality assay (LD50>1 mg/mL), compounds 1 and 2 displayed significant antioxidant activity in the DPPH assay (RC50 = 0.0976 mg/mL and 0.0148 mg/mL, respectively).