The modified Wilson model and predicting drug solubility in water- cosolvent mixtures

dc.contributor.author	Jouyban-Gharamaleki, A
dc.date.accessioned	2018-08-26T09:40:57Z
dc.date.available	2018-08-26T09:40:57Z
dc.date.issued	1998
dc.identifier	10.1248/cpb.46.1058
dc.identifier.uri	http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/58436
dc.description.abstract	Applicability of the modified Wilson model for calculating drug solubility in water-cosolvent mixtures is presented. The accuracy and predictability of the model are compared with those of other models which calculate solute solubility as a function of the solvent composition. Mean of percent deviations from experimental values are 7.77, 8.70, 9.06, 10.72, 10.72 and 18.71, for the modified Wilson, double-log exponential, general single model, combined nearly ideal binary solvent/Redlich-Kister, excess free energy and mixture response surface methods, respectively.
dc.language.iso	English
dc.relation.ispartof	Chemical and Pharmaceutical Bulletin
dc.subject	solvent
dc.subject	water
dc.subject	accuracy
dc.subject	article
dc.subject	drug formulation
dc.subject	drug solubility
dc.subject	model
dc.title	The modified Wilson model and predicting drug solubility in water- cosolvent mixtures
dc.type	Article
dc.citation.volume	46
dc.citation.issue	6
dc.citation.spage	1058
dc.citation.epage	1061
dc.citation.index	Scopus