The effect of loganin on passive avoidance learning in diabetic male rats

Abstract

Objective: Diabetes is associated with memory and learning disorder. The purpose of this study is to determine the effect of loganin on memory and passive avoidance learning in diabetic male rats. Methods: 42 male Wistar rats (250-300 g) were divided into six groups (Control, Diabetic 1 week, Diabetic 12 week, Loganin, Diabetic 1 week + Loganin, Diabetic 12weeks + Loganin). Diabetes is induced by IP injection of Streptozotocin (60mg/kg). Loganin was administrated 1 hour befor test (40mg/kg,po). Then, passive avoidance learning were compared between groups with shuttle box. Results: Administration of loganin increased step through latency significantly (p<0.05) and time spent in light compartment of shuttle box in diabetic 1 week and 12 weeks that recieved loganin. Conclusion: Loganin improved passive avoidance learning in diabetic groups that recived loganin.