Solubilization of naproxen using N-methyl-2-pyrrolidone or ethanol and ?-cyclodextrin

Abstract

Solubility trend of naproxen in the presence of 5 and 10 mM of ?-CD was measured at 298.2 K and compared with solubility profiles in the absence of ?-CD for water + cosolvent mixtures. The saturated solutions of the given volume fractions were reached using shake-flask method, and then the solubility values were measured by UV spectrophotometric method at 256 nm. Afterwards, the experimental solubility data points of naproxen in water + ethanol (EtOH) and water + N-methyl-2-pyrrolidone with and without ?-cyclodextrin (?-CD) were correlated with Jouyban-Acree model. Calculation results revealed that the back-calculated solubilities were in good agreement with the corresponding experimental values. By applying the correlated equations, one can rapidly predict the solubility of naproxen in all solvent compositions. © 2017 Informa UK Limited, trading as Taylor & Francis Group