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Solubility of sildenafil citrate in polyethylene glycol 400 + water mixtures at various temperatures

dc.contributor.authorPirhayati, FH
dc.contributor.authorShayanfar, A
dc.contributor.authorRahimpour, E
dc.contributor.authorBarzegar-Jalali, M
dc.contributor.authorMartinez, F
dc.contributor.authorJouyban, A
dc.date.accessioned2018-08-26T09:35:42Z
dc.date.available2018-08-26T09:35:42Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57903
dc.description.abstractThe solubility of sildenafil citrate (SC) in binary aqueous mixtures of polyethylene glycol 400 (PEG 400) were determined at 293.2, 298.2, 303.2, 308.2 and 313.2 K. Density of the SC saturated solutions over the entire solvent composition and temperature range was measured by a pycnometer. The solubility and densities data were correlated by two models, which are the van't Hoff and Jouyban-Acree model. The apparent thermodynamic properties, dissolution enthalpy, dissolution entropy, and Gibbs free energy change of dissolution process of SC in all the mixed solvents were calculated according to van't Hoff and Gibbs equations. © 2017 Elsevier B.V.
dc.language.isoEnglish
dc.relation.ispartofJournal of Molecular Liquids
dc.subjectBinary mixtures
dc.subjectBins
dc.subjectDensity (specific gravity)
dc.subjectDissolution
dc.subjectFree energy
dc.subjectGibbs free energy
dc.subjectMixtures
dc.subjectPolyethylene glycols
dc.subjectPolyethylenes
dc.subjectSolvents
dc.subjectBinary solvent mixtures
dc.subjectDissolution enthalpies
dc.subjectDissolution entropies
dc.subjectGibbs free energy changes
dc.subjectJouyban-Acree model
dc.subjectPolyethylene glycol 400
dc.subjectSildenafil citrate
dc.subjectVan't Hoff equation
dc.subjectSolubility
dc.titleSolubility of sildenafil citrate in polyethylene glycol 400 + water mixtures at various temperatures
dc.typeArticle
dc.citation.volume240
dc.citation.spage268
dc.citation.epage272
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.molliq.2017.05.057


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