Solubility of methocarbamol in some cosolvent + water mixtures at 298.15 K and correlation with the Jouyban-Acree model

Abstract

Equilibrium solubility of methocarbamol was determined in binary mixtures of dioxane, polyethylene glycol 400, ethanol, methanol or propylene glycol, and water at 298.15 K. From maximum values in drug solubility and theoretical calculations involving the method proposed by Fedors a discussion was made about the Hildebrand solubility parameter for this drug. On the other hand, solubility values were correlated and/or predicted with the Jouyban-Acree model. The overall mean percentage deviations for the correlated and predicted solubilities were 2.7% and 89.0%, respectively. Finally, density of saturated and drug free solution binary solvent mixtures was also calculated using the Jouyban-Acree model. © 2013 Elsevier B.V.