Solubility of lamotrigine and diazepam in propylene glycol + water + carboxymethyl cellulose at a temperature of 298.2 K

Abstract

The simultaneous effects of propylene glycol and carboxymethyl cellulose (CMC) on the solubility of two antiepileptic drugs, 6-(2,3-dichlorophenyl)-1,2, 4-triazine-3,5-diamine (commonly known as lamotrigine) and 7-chloro-1-methyl-5- phenyl-3//-1,4-benzodiazepin-2-one (commonly known as diazepam), at T = 298.2 K were investigated. The aqueous solubility of drugs in the presence of propylene glycol and different concentrations of CMC [(0.02, 0.2, 1, and 2) g L-1] increased. The data were fit to a modified version of the Jouyban-Acree model for modeling the simultaneous effects of the cosolvent and polymer on the solubility of drugs. The overall mean relative deviation (MRD) was 15.8 %, and the solubilities of drugs could be predicted at different propylene glycol and CMC concentrations using an interpolation technique. © 2010 American Chemical Society.