Solubility of acetaminophen and ibuprofen in polyethylene glycol 600, propylene glycol and water mixtures at 25 °c

Abstract

The solubilities of acetaminophen and ibuprofen in the mixtures of propylene glycol-water, of polyethylene glycol 600-propylene glycol, and of polyethylene glycol 600-propylene glycol-water at 25 °C are determined and mathematically represented by the Jouyban-Acree model. The solubilities are measured using the shake flask method and the model is used to fit the solubility data of each drug in the solvent mixtures. The density of the solute-free solvent mixtures is measured and employed to train the Jouyban-Acree model and then the density of the saturated solutions is predicted. The obtained overall mean relative deviations (OMRDs) for fitting the solubility data of acetaminophen and ibuprofen in binary mixtures are 1.4% and 11.2%, respectively. The OMRDs for fitting the solubilities in ternary solvent mixtures for acetaminophen and ibuprofen are 16.5% and 37.5%, respectively, and the OMRD values for predicting all solubilities of acetaminophen and ibuprofen by these trained versions of the Jouyban-Acree model were 5.2% and 17.8%, respectively. The prediction of OMRD for the density of saturated solutions was 2.2%. © 2010 Elsevier B.V. All rights reserved.