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dc.contributor.authorJouyban, A
dc.contributor.authorShokri, J
dc.contributor.authorBarzegar-Jalali, M
dc.contributor.authorHassanzadeh, D
dc.contributor.authorAcree Jr
dc.contributor.authorWE
dc.contributor.authorGhafourian, T
dc.contributor.authorNokhodchi, A
dc.date.accessioned2018-08-26T09:35:22Z
dc.date.available2018-08-26T09:35:22Z
dc.date.issued2010
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57863
dc.description.abstractExperimental solubilities of 7-chloro-2-methylamino-5-phenyl-3H-1,4- benzodiazepine-4-oxide (chlordiazepoxide), 7-chloro-1,3-dihydro-1-methyl-5- phenyl-2H-1,4-benzodiazepin-2-one (diazepam), and 7-chloro- 5-(2-chlorophenyl)- 3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one (lorazepam) in (propane-1,2-diol + water) at T = 303.2 K were reported. The solubility of drugs increased with the addition of propane-1,2-diol and reached the maximum values in pure propane-1,2-diol. The Jouyban-Acree model was used to fit the experimental data, and the solubilities were reproduced using a previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the back-calculated and predicted values with the corresponding experimental data were 4.2% and 10.7%. The solubilities of the three drugs were also predicted using a trained version of the log-linear model of Yalkowsky, and the OMRD was 21.1%. ط¢آ© 2010 American Chemical Society.
dc.language.isoEnglish
dc.relation.ispartofJournal of Chemical and Engineering Data
dc.subjectExperimental data
dc.subjectJouyban-Acree model
dc.subjectLoglinear model
dc.subjectLorazepam
dc.subjectMaximum values
dc.subjectRelative deviations
dc.subjectSolubility data
dc.subjectPropane
dc.subjectRegression analysis
dc.subjectTernary systems
dc.subjectSolubility
dc.titleSolubility of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4- oxide,7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (propane-1,2-diol + water) at a temperature of 303.2 K
dc.typeArticle
dc.citation.volume55
dc.citation.issue1
dc.citation.spage539
dc.citation.epage542
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1021/je900451d


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