dc.contributor.author | Jouyban, A | |
dc.contributor.author | Shokri, J | |
dc.contributor.author | Barzegar-Jalali, M | |
dc.contributor.author | Hassanzadeh, D | |
dc.contributor.author | Acree Jr | |
dc.contributor.author | WE | |
dc.contributor.author | Ghafourian, T | |
dc.contributor.author | Nokhodchi, A | |
dc.date.accessioned | 2018-08-26T09:35:22Z | |
dc.date.available | 2018-08-26T09:35:22Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57863 | |
dc.description.abstract | Experimental solubilities of 7-chloro-2-methylamino-5-phenyl-3H-1,4- benzodiazepine-4-oxide (chlordiazepoxide), 7-chloro-1,3-dihydro-1-methyl-5- phenyl-2H-1,4-benzodiazepin-2-one (diazepam), and 7-chloro- 5-(2-chlorophenyl)- 3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one (lorazepam) in (propane-1,2-diol + water) at T = 303.2 K were reported. The solubility of drugs increased with the addition of propane-1,2-diol and reached the maximum values in pure propane-1,2-diol. The Jouyban-Acree model was used to fit the experimental data, and the solubilities were reproduced using a previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the back-calculated and predicted values with the corresponding experimental data were 4.2% and 10.7%. The solubilities of the three drugs were also predicted using a trained version of the log-linear model of Yalkowsky, and the OMRD was 21.1%. ط¢آ© 2010 American Chemical Society. | |
dc.language.iso | English | |
dc.relation.ispartof | Journal of Chemical and Engineering Data | |
dc.subject | Experimental data | |
dc.subject | Jouyban-Acree model | |
dc.subject | Loglinear model | |
dc.subject | Lorazepam | |
dc.subject | Maximum values | |
dc.subject | Relative deviations | |
dc.subject | Solubility data | |
dc.subject | Propane | |
dc.subject | Regression analysis | |
dc.subject | Ternary systems | |
dc.subject | Solubility | |
dc.title | Solubility of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4- oxide,7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (propane-1,2-diol + water) at a temperature of 303.2 K | |
dc.type | Article | |
dc.citation.volume | 55 | |
dc.citation.issue | 1 | |
dc.citation.spage | 539 | |
dc.citation.epage | 542 | |
dc.citation.index | Scopus | |
dc.identifier.DOI | https://doi.org/10.1021/je900451d | |