Solubility of 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2- one, 7-Chloro-1-methyl-5-phenyl-3 H -1,4-benzodiazepin-2-one, and 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine in the mixtures of Poly(ethylene glycol) 600, ethanol, and water at a temperature of 298.2 K

Abstract

Experimental solubilities of 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4- benzodiazepin-2-one (clonazepam), 7-chloro-1-methyl-5-phenyl-3H-1,4- benzodiazepin-2-one (diazepam), and 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5- diamine (lamotrigine) in poly(ethylene glycol) (PEG) 600 (1) + ethanol (2), PEG 600 (1) + water (3), and PEG 600 (1) + ethanol (2) + water (3) mixtures at T = 298.2 K are reported. The Jouyban-Acree model was used to fit the solubility data of each drug in the ternary and sub-binary solvent mixtures in which the mean deviations for clonazepam, diazepam, and lamotrigine were 6.1 %, 8.3 %, and 10.9 %, respectively, and the overall value was 8.4 %. © 2009 American Chemical Society.