Solubility and apparent specific volume at saturation of some pharmaceutical salts in methanol + water mixtures at 298.15 K

Abstract

Equilibrium solubility of sodium naproxen (Na·NAP), procaine hydrochloride (PC·HCl), and lysine clonixinate (Lys.Clon), was determined in methanol + water mixtures at 298.15 K. Mole fraction solubility of Na·NAP increases from neat water to reach a maximum in the mixture with w1 = 0.90; the solubility of PC·HCl increases from neat water to reach a maximum in the mixture with w1 = 0.20; whereas, the solubility of Lys.Clon increases from neat water to reach a maximum in the mixture with w1 = 0.60. The generated solubility data are mathematically represented by using the Jouyban-Acree model with very good error level. In addition, the apparent specific volumes at saturation of these drugs were also calculated in all the mixtures under study using the measured densities of the saturated solutions. © 2016 Elsevier B.V.