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Secretases-related miRNAs in Alzheimer's disease: new approach for biomarker discovery

dc.contributor.authorHajjari, SN
dc.contributor.authorMehdizadeh, M
dc.contributor.authorSadigh-Eteghad, S
dc.contributor.authorShanehbandi, D
dc.contributor.authorTeimourian, S
dc.contributor.authorBaradaran, B
dc.date.accessioned2018-08-26T09:34:27Z
dc.date.available2018-08-26T09:34:27Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57738
dc.description.abstractAmyloid-? (A?) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by ?- and ?-secretaseâ€"‌in amyloidogenesis pathway. Products of ?-secretase cleavage also have protective effects against A? toxicity. According to existing evidences, microRNAs (miRNAs) show a unique pattern of expression in AD. Moreover, miRNAs regulatory effects on expression of secretases and their main components have been demonstrated in AD. The miRNAs levels may be changed in preclinical conditions and may be considered as diagnostic biomarkers in AD. Therefore, in this paper, we review the miRNAs involved in APP cleavage pathways and the formation of A? in order to evaluate the potential diagnostic biomarkers in AD. © 2017, Springer-Verlag Italia S.r.l.
dc.language.isoEnglish
dc.relation.ispartofNeurological Sciences
dc.subjectalpha secretase
dc.subjectamyloid beta protein
dc.subjectamyloid precursor protein
dc.subjectanterior pharynx defective 1 protein
dc.subjectbeta secretase 1
dc.subjectgamma secretase
dc.subjectmicroRNA
dc.subjectnicastrin
dc.subjectpresenilin 1
dc.subjectpresenilin 2
dc.subjectsecretase
dc.subjectbiological marker
dc.subjectmicroRNA
dc.subjectsecretase
dc.subjectAlzheimer disease
dc.subjectclinical evaluation
dc.subjecthuman
dc.subjectmolecular biology
dc.subjectnonhuman
dc.subjectprotein analysis
dc.subjectprotein expression
dc.subjectReview
dc.subjectsignal transduction
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjectmetabolism
dc.subjectAlzheimer Disease
dc.subjectAmyloid Precursor Protein Secretases
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectHumans
dc.subjectMicroRNAs
dc.titleSecretases-related miRNAs in Alzheimer's disease: new approach for biomarker discovery
dc.typeArticle
dc.citation.volume38
dc.citation.issue11
dc.citation.spage1921
dc.citation.epage1926
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1007/s10072-017-3086-3


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