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Regulation of nicotinic acetylcholine receptors in Alzheimer>s disease: A possible role of chaperones

dc.contributor.authorSadigh-Eteghad, S
dc.contributor.authorMajdi, A
dc.contributor.authorTalebi, M
dc.contributor.authorMahmoudi, J
dc.contributor.authorBabri, S
dc.date.accessioned2018-08-26T09:33:29Z
dc.date.available2018-08-26T09:33:29Z
dc.date.issued2015
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57566
dc.description.abstractAbstract Nicotinic acetylcholine receptors (nAChRs) seem to play an integral role in the progress and/or prevention of Alzheimer>s diseases (AD). Functional abnormalities and problems in biogenesis and trafficking of nAChRs are two major culprits in AD; on the other hand, chaperones modulate post-translational changes in nAChRs. Moreover, they indirectly regulate nAChRs by controlling AD-related proteins such as tau and amyloid beta (A?). In this review, we go through recent studies which are showing that chaperones modulate the expression of nAChRs in a subtype-specific manner and explain how AD progress is affected by nAChRs chaperoning. é 2015 Elsevier B.V. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofEuropean Journal of Pharmacology
dc.subject14 3 3 chaperone
dc.subjectbungarotoxin receptor
dc.subjectchaperone
dc.subjectmembrane protein
dc.subjectnicotine
dc.subjectnicotinic receptor
dc.subjectnicotinic receptor alpha4beta2
dc.subjectresistant to inhibitor of cholinesterase 3 protein
dc.subjecttau protein
dc.subjecttoll like receptor
dc.subjectubiquilin 1
dc.subjectubiquitin
dc.subjectunclassified drug
dc.subjectvisinin
dc.subjectchaperone
dc.subjectnicotinic receptor
dc.subjectAlzheimer disease
dc.subjectcytokine release
dc.subjectdisease severity
dc.subjecthuman
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectprotein assembly
dc.subjectprotein conformation
dc.subjectprotein degradation
dc.subjectprotein expression
dc.subjectprotein folding
dc.subjectprotein function
dc.subjectprotein phosphorylation
dc.subjectprotein protein interaction
dc.subjectprotein transport
dc.subjectReview
dc.subjectupregulation
dc.subjectAlzheimer disease
dc.subjectbrain
dc.subjectmetabolism
dc.subjectAlzheimer Disease
dc.subjectBrain
dc.subjectHumans
dc.subjectMolecular Chaperones
dc.subjectReceptors, Nicotinic
dc.titleRegulation of nicotinic acetylcholine receptors in Alzheimer>s disease: A possible role of chaperones
dc.typeArticle
dc.citation.volume755
dc.citation.spage35
dc.citation.epage41
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.ejphar.2015.02.047


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