dc.contributor.author | Ghaderi, F | |
dc.contributor.author | Nemati, M | |
dc.contributor.author | Siahi-Shadbad, MR | |
dc.contributor.author | Valizadeh, H | |
dc.contributor.author | Monajjemzadeh, F | |
dc.date.accessioned | 2018-08-26T09:31:56Z | |
dc.date.available | 2018-08-26T09:31:56Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57212 | |
dc.description.abstract | In the present study the physicochemical stability of sertraline with lactose was evaluated in drug-excipient binary mixtures. Different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy, and mass spectrometry were applied to confirm the incompatibility. The final aim of this study was to evaluate the kinetic parameters using a fast and sensitive DSC method. Solid-state kinetic parameters were derived from nonisothermally stressed physical mixtures using different thermal models such as Friedman, Flynnأ¢â‚¬â€œWallأ¢â‚¬â€œOzawa, and Kissingerأ¢â‚¬â€œAkahiraأ¢â‚¬â€œSunose. Overall, the instability of sertraline with lactose was successfully evaluated. Further confirmation was made by tracking the Maillard reaction product of sertraline and lactose by mass spectrometry. DSC scans provided important information about the stability of sertraline in solid-state condition and also revealed the related thermokinetic parameters in order to understand the nature of the chemical instability. ط¢آ© 2016 | |
dc.language.iso | English | |
dc.relation.ispartof | Journal of Food and Drug Analysis | |
dc.subject | lactose | |
dc.subject | sertraline | |
dc.subject | excipient | |
dc.subject | lactose | |
dc.subject | sertraline | |
dc.subject | Article | |
dc.subject | chemical reaction kinetics | |
dc.subject | differential scanning calorimetry | |
dc.subject | drug stability | |
dc.subject | glycation | |
dc.subject | heating | |
dc.subject | infrared spectroscopy | |
dc.subject | mass spectrometry | |
dc.subject | melting point | |
dc.subject | solid state | |
dc.subject | thermostability | |
dc.subject | chemical phenomena | |
dc.subject | chemistry | |
dc.subject | differential scanning calorimetry | |
dc.subject | drug stability | |
dc.subject | infrared spectroscopy | |
dc.subject | kinetics | |
dc.subject | medicinal chemistry | |
dc.subject | temperature | |
dc.subject | Calorimetry, Differential Scanning | |
dc.subject | Chemical Phenomena | |
dc.subject | Chemistry, Pharmaceutical | |
dc.subject | Drug Stability | |
dc.subject | Excipients | |
dc.subject | Kinetics | |
dc.subject | Lactose | |
dc.subject | Sertraline | |
dc.subject | Spectroscopy, Fourier Transform Infrared | |
dc.subject | Temperature | |
dc.title | Physicochemical analysis and nonisothermal kinetic study of sertraline–lactose binary mixtures | |
dc.type | Article | |
dc.citation.volume | 25 | |
dc.citation.issue | 3 | |
dc.citation.spage | 709 | |
dc.citation.epage | 716 | |
dc.citation.index | Scopus | |
dc.identifier.DOI | https://doi.org/10.1016/j.jfda.2016.08.003 | |