Patients' report of statins use and side-effects in a sample of hospitalized cardiac patients in the islamic Republic of Iran [Utilisation des statines et signalement d'effets secondaires dans un é chantillon de patients atteints de cardiopathies et hospitalisé s en Ré publique islamique d'Iran]

Abstract

We aimed to study the prevalence of the side-effects of statins among Iranians patients admitted to a cardiac-specialized hospital and had taken statins prior to hospitalization. Data was collected between September 2007 and March 2008 and 200 patients were enrolled. A questionnaire was completed using the patients' records and by interviewing the patients. The mean age of the participants was 61.5 (SD 12.3) years and 63% were males. The most commonly used statins was atrovastatin (99% of the patients). In all, 63.5% of the participants reported experiencing side-effects due to statins. The reported side-effects were respiratory (4%) and gastrointestinal effect (18.5%), headache (16.5%), rash (0.5%) and allergic reactions (5%); 9.5% reported muscle-related side-effects such as myalgia. Although, the clinical benefits outweigh the small risk of liver failure and myopathy, clinicians should be aware of the side-effects of statins.