نمایش پرونده ساده آیتم

dc.contributor.authorMahrooz, A
dc.contributor.authorNouri, M
dc.contributor.authorRashidi, MR
dc.contributor.authorAslanabadi, N
dc.contributor.authorQujeq, D
dc.contributor.authorAzari, A
dc.date.accessioned2018-08-26T09:31:41Z
dc.date.available2018-08-26T09:31:41Z
dc.date.issued2008
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57136
dc.description.abstractIntroduction: Considering the importance of serum paraoxonase (PON1) in preventing from production of oxidized low-density lipoprotein (LDL), and consequently, its role in prohibiting from development of atherosclerosis, we investigated paraoxonase and arylesterase activities of PON1 in patients with coronary artery disease (CAD) and with different coronary stenosis. Materials and Methods: In the present study, 120 patients with CAD were examined and their stenosis documented by coronary angiography. Then, the patients were divided into two groups: 60 patients with less than 50% of stenosis and 60 patients with more than 70% of stenosis. Paraoxonase and arylesterase activity was measured with substrates of paraoxon and phenylacetate, respectively. The effects of eight drugs, which are prescribed in cardiovascular diseases, were assayed on paraoxonase activity. Results: There were no significant differences in LDL-C, total cholesterol and triglyceride levels between two groups, but HDL levels in patients with >70% of stenosis were significantly decreased as compared with those of patients who had <50% of stenosis (P<0.03). Both paraoxonase and arylesterase activity in patients with >70% of stenosis were significantly lower (P<0.05) than patients with<50% of stenosis. Conclusion: Paraoxonase and arylesterase activities of PON1 and HDL levels in patients with >70% of stenosis were lower than patients with <50% of stenosis. In other words, the PON1 activities and HDL levels decrease with progression of atheroma. Therefore, the study might support the important role of HDL-bound PON1 in preventing from formation of ox-LDL and its anti-atherogenic activity.
dc.language.isoArabic
dc.relation.ispartofKoomesh
dc.subjectaryldialkylphosphatase 1
dc.subjectarylesterase
dc.subjecthigh density lipoprotein
dc.subjectlow density lipoprotein cholesterol
dc.subjectparaoxon
dc.subjectphenylacetic acid
dc.subjecttriacylglycerol
dc.subjectangiocardiography
dc.subjectarticle
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectcoronary artery obstruction
dc.subjectenzyme activity
dc.subjectenzyme substrate
dc.subjecthuman
dc.subjectlipoprotein blood level
dc.subjectmajor clinical study
dc.subjecttriacylglycerol blood level
dc.titleParaoxonase and Arylesterase activities of human serum paraoxonase in coronary artery disease
dc.typeReview
dc.citation.volume10
dc.citation.issue1
dc.citation.spage1
dc.citation.epage6+1
dc.citation.indexScopus


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