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dc.contributor.authorIlghami, A
dc.contributor.authorGhanbarzadeh, S
dc.contributor.authorHamishehkar, H
dc.date.accessioned2018-08-26T09:31:31Z
dc.date.available2018-08-26T09:31:31Z
dc.date.issued2015
dc.identifier10.15171/PS.2015.16
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57086
dc.description.abstractBackground: Phenolic compounds act as receiver of the free radicals and antioxidant activity of the extracts has high correlation with these compounds amount. Ultrasonic-assisted extraction (UAE) presently is an interesting technique for recovering the valuable compounds from the vegetal materials. The aim of this research was optimization of the extraction condition of UAE using response surface methodology (RSM). Methods: Effects of extraction time and ultrasound intensity on the total phenolic contents (TPC), antioxidant properties, as well as ferric reducing antioxidant power (FRAP) of Beta vulgaris extract were investigated. Results: The results showed that 92.68% of intensity and 15.85 min were the optimum extraction condition for highest TPC extraction. The amount of TPC, EC50 and FRAP in extract of Beta vulgaris in optimum conditions of UAE were equal to 0.916 mg gallic acid/g of extract, 0.937 mg/mL and 1.20 mmol/mL, respectively. Therefore, results showed that ultrasound intencity has a positive effect on the extraction efficiency of phenolic compounds and ferric reducing antioxidant power, but has a negative effect on the free radical scavenging ability. Conclusion: It can be concluded that the extraction efficacy of Beta vulgaris extract could be enhanced significantly by optimization of the extraction process by means of RSM. ط¢آ©2015 The Authors.
dc.language.isoEnglish
dc.relation.ispartofPharmaceutical Sciences
dc.subjectgallic acid
dc.subjectphenol derivative
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectbeet
dc.subjectconcentration (parameters)
dc.subjectdrug activity
dc.subjectEC50
dc.subjectextraction
dc.subjectferric reducing activity
dc.subjectfree radical scavenging assay
dc.subjectpharmacological procedures
dc.subjectphysical parameters
dc.subjectresponse surface method
dc.subjecttime
dc.subjectultrasonic assisted extraction
dc.subjectultrasound intensity
dc.titleOptimization of the ultrasonic-assisted extraction of phenolic compounds, ferric reducing activity and antioxidant activity of the Beta vulgaris using response surface methodology
dc.typeArticle
dc.citation.volume21
dc.citation.issue1
dc.citation.spage46
dc.citation.epage50
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.15171/PS.2015.16


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