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Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000 copolymer

dc.contributor.authorEbrahimi, E
dc.contributor.authorAkbarzadeh, A
dc.contributor.authorAbbasi, E
dc.contributor.authorKhandaghi, AA
dc.contributor.authorAbasalizadeh, F
dc.contributor.authorDavaran, S
dc.date.accessioned2018-08-26T09:31:22Z
dc.date.available2018-08-26T09:31:22Z
dc.date.issued2016
dc.identifier10.3109/21691401.2014.944646
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57029
dc.description.abstractNew drug delivery systems delivered the active molecules to the target site in a definite manner to produce the desired effects without disturbing the delicate bio-environment. The Fe3O4 magnetic nanoparticles were prepared by chemical precipitation of Fe salts in the ratio of 1: 2 under alkaline and inert condition. PLGA-PEG1000 triblock copolymer was synthesized by ring-opening polymerization. The properties of this copolymer were characterized using Fourier transform infrared spectroscopy. In addition, the resulting particles were characterized by X-ray powder diffraction, scanning electron microscopy, and vibrating sample magnetometry. The in vitro doxorubicin (DOX) release profiles were obtained by representing the percentage of DOX release. In this report, we used this new method to fabricate PEGylated PLGA particles, and examined the anticancer agent DOX. © Copyright 2014 Informa Healthcare USA, Inc.
dc.language.isoEnglish
dc.relation.ispartofArtificial Cells, Nanomedicine and Biotechnology
dc.subjectAlkalinity
dc.subjectFourier transform infrared spectroscopy
dc.subjectFunctional polymers
dc.subjectMedical applications
dc.subjectNanomagnetics
dc.subjectNanoparticles
dc.subjectPolyethylene glycols
dc.subjectPolyethylene oxides
dc.subjectRing opening polymerization
dc.subjectScanning electron microscopy
dc.subjectX ray powder diffraction
dc.subjectBiomedical applications
dc.subjectChemical precipitation
dc.subjectDoxorubicin
dc.subjectDrug delivery system
dc.subjectMagnetic nano-particles
dc.subjectPLGA
dc.subjectPolymeric nanoparticles
dc.subjectVibrating sample magnetometry
dc.subjectPrecipitation (chemical)
dc.subjectdoxorubicin
dc.subjectiron salt
dc.subjectmacrogol 10000
dc.subjectmagnetite nanoparticle
dc.subjectpolyglactin
dc.subjectantineoplastic antibiotic
dc.subjectdoxorubicin
dc.subjectlactic acid
dc.subjectmacrogol derivative
dc.subjectmagnetite
dc.subjectmagnetite nanoparticle
dc.subjectpolyethylene glycol 1000
dc.subjectpolyglycolic acid
dc.subjectpolylactic acid-polyglycolic acid copolymer
dc.subjectArticle
dc.subjectdrug delivery system
dc.subjectdrug release
dc.subjectin vitro study
dc.subjectinfrared spectroscopy
dc.subjectmagnetometry
dc.subjectnanoencapsulation
dc.subjectprecipitation
dc.subjectring opening metathesis polymerization
dc.subjectscanning electron microscopy
dc.subjectX ray powder diffraction
dc.subjectchemistry
dc.subjectdrug delivery system
dc.subjectdrug formulation
dc.subjectpolymerization
dc.subjectprocedures
dc.subjectultrastructure
dc.subjectAntibiotics, Antineoplastic
dc.subjectChemical Precipitation
dc.subjectDoxorubicin
dc.subjectDrug Compounding
dc.subjectDrug Delivery Systems
dc.subjectDrug Liberation
dc.subjectFerrosoferric Oxide
dc.subjectLactic Acid
dc.subjectMagnetite Nanoparticles
dc.subjectPolyethylene Glycols
dc.subjectPolyglycolic Acid
dc.subjectPolymerization
dc.subjectSpectroscopy, Fourier Transform Infrared
dc.titleNovel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000 copolymer
dc.typeArticle
dc.citation.volume44
dc.citation.issue1
dc.citation.spage290
dc.citation.epage297
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.3109/21691401.2014.944646


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