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Investigating the frequency of the ERCC1 Gene C8092A polymorphism in Iranian patients with advanced gastric cancer

dc.contributor.authorMokmeli, S
dc.contributor.authorTehrani, GA
dc.contributor.authorZamiri, RE
dc.contributor.authorBahrami, T
dc.date.accessioned2018-08-26T08:59:00Z
dc.date.available2018-08-26T08:59:00Z
dc.date.issued2016
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54760
dc.description.abstractBackground: Platinum compounds are the main drugs for treatment of advanced gastric cancer. Previous studies have shown that clinical outcome with platinum-based compounds depends on ERCC1 polymorphisms. The aim of this study was to investigate the frequency of a common polymorphism of ERCC1 gene (C8092A) in Iranian patients with advanced gastric cancer receiving platinum chemotherapy. Materials and Methods: Genetic analysis of the ERCC1 C8092A polymorphism was performed by the PCR - RFLP method using 50 paraffin-embedded tissue specimens. Results: Of the 50 cases, 32% of individuals showed CC genotype, 24% of them had CA genotype and 44% of patients had AA genotype. Conclusions: Based on the results, using of platinum-based chemotherapy would be expected to be specifically beneficial in only 32% of patients.
dc.language.isoEnglish
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.subjectDNA binding protein
dc.subjectendonuclease
dc.subjectERCC1 protein, human
dc.subjectplatinum derivative
dc.subjecttumor marker
dc.subjectcancer grading
dc.subjectfemale
dc.subjectfollow up
dc.subjectgenetics
dc.subjectgenotype
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectpolymerase chain reaction
dc.subjectprognosis
dc.subjectrestriction fragment length polymorphism
dc.subjectsingle nucleotide polymorphism
dc.subjectStomach Neoplasms
dc.subjectsurvival rate
dc.subjectBiomarkers, Tumor
dc.subjectDNA-Binding Proteins
dc.subjectEndonucleases
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Grading
dc.subjectPlatinum Compounds
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPrognosis
dc.subjectStomach Neoplasms
dc.subjectSurvival Rate
dc.titleInvestigating the frequency of the ERCC1 Gene C8092A polymorphism in Iranian patients with advanced gastric cancer
dc.typeArticle
dc.citation.volume17
dc.citation.issue3
dc.citation.spage1369
dc.citation.epage1372
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.7314/APJCP.2016.17.3.1369


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