نمایش پرونده ساده آیتم

dc.contributor.authorMoghadaszadeh, M
dc.contributor.authorNikanfar, A
dc.contributor.authorHemati, M
dc.contributor.authorGharib, B
dc.contributor.authorSardashti, S
dc.date.accessioned2018-08-26T08:58:47Z
dc.date.available2018-08-26T08:58:47Z
dc.date.issued2010
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54736
dc.description.abstractIntroduction: Breast cancer is the most common malignancy with more than one million new cases diagnosed annually all around the world. Its growth is mostly regulated by steroid hormones such as estrogen and peptide growth factors in interaction with epidermal growth factor 1 and 2. Methods and materials: In this study, 237 patients who had consulted the Oncology Clinic of Tabriz University of Medical Sciences with pathologic diagnosis of breast cancer (from 2003 to 2010) were involved. Data was extracted from medical record. Results: From the total of 237 patients, 50.6% were ER+, 48.9% were PR+ and 37.1% were HER-2+. The greatest percentage of HER-2 positivity (51.6%) was detected in the age group of patients over 60 and the least in the group aged 31 to 40 yrs. The greatest percentage of HR+ (71%) patients were also over 60 and the least (50%) were less than 30. 35.5% of patients in pre- menstrual period were HER-2+. HR was positive in 64% of LN+ patients; HER- 2 and HR were positive in 35.4% and 65.4% while in LN- patients they were positive in 39% and 61.9% of cases, respectively. Conclusion: Acquired data showed reverse relation between the expression of epidermal growth factor II and hormone receptors in breast cancer. 40-55% of cases with epidermal growth factor expression lacked hormone receptors. Co-existence of hormone receptors and HER-2 expression in breast cancer are considered as important prognostic factors.
dc.language.isoEnglish
dc.relation.ispartofInternational Journal of Hematology-Oncology and Stem Cell Research
dc.subjectepidermal growth factor receptor 2
dc.subjectestrogen receptor
dc.subjectprogesterone receptor
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbone metastasis
dc.subjectbreast cancer
dc.subjectcancer staging
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectfemale
dc.subjecthuman
dc.subjectlung metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmenstrual cycle
dc.subjectpatient assessment
dc.subjectpleura metastasis
dc.subjectprognosis
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectprotein protein interaction
dc.titleInteraction between HER-2 and hormone receptors in breast cancer
dc.typeArticle
dc.citation.volume4
dc.citation.issue4
dc.citation.spage14
dc.citation.epage16
dc.citation.indexScopus


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