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dc.contributor.authorRahim, G
dc.contributor.authorSaeed, S-E
dc.date.accessioned2018-08-26T08:58:35Z
dc.date.available2018-08-26T08:58:35Z
dc.date.issued2015
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54712
dc.description.abstractThe inhibitory activity of butylated hydroxyanizole (BHA) alone and at different pH (3.5 and 5.5) and different NaCl concentrations (2 and 4%) was screened on 5 molds and 3 yeasts. The conventional tube test was used to determine the minimum inhibitory concentration (MIC). BHA was effective against all of the microorganisms tested in the range of 20 to 320 ?g/mL. The inhibition was pronounced at lowering pH and at NaCl concentrations. BHA was more effective in the presence of NaCl compared to acidic conditions. The MIC values of BHA was significantly lesser in media containing 4% and 2% NaC1 (p< 0.05). Rhizopus arrhizus RAK 220 was the most susceptible fungi to NaCl concentrations. In the presence of 2% NaCl concentration, the MIC value of BHA for Rhizopus arrhizus RAK 220 was reduced to 1/4. The decrease in pH values from 7 to 5.5 and 3.5 had synergistic effect on the inhibitory activity of BHA on some microorganisms (p< 0.05). Among the tests, Geotrichum candidum UUFH 110 was the most susceptible fungi to reduce the pH values, as at pH 5.5 the MIC values of BHA reduced to. and at pH 3.5 reduced to one-sixth. In contrast, at different pH, the MIC values of BHA on Candida albicans CAL 512 not only not decreased but also increased. These studies show that the antifungal properties of BHA can be greatly influenced by environmental factors. é 2015 DAR Publishers. The University of Jordan. All Rights Reserved.
dc.language.isoEnglish
dc.relation.ispartofJordan Medical Journal
dc.subjectantifungal agent
dc.subjectbutylated hydroxyanisole
dc.subjectsodium chloride
dc.subjectacidity
dc.subjectantifungal activity
dc.subjectArticle
dc.subjectAspergillus flavus
dc.subjectAspergillus fumigatus
dc.subjectAspergillus niger
dc.subjectCandida albicans
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectfungus growth
dc.subjectGeotrichum candidum
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectPenicillium
dc.subjectRhizopus oryzae
dc.subjectRhodotorula mucilaginosa
dc.titleInhibitory effects of butylated hydroxyanisole on growth of molds and yeasts at different pH conditions and different NaCl concentrations
dc.typeArticle
dc.citation.volume49
dc.citation.issue3
dc.citation.spage139
dc.citation.epage145
dc.citation.indexScopus


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