IL-4 regulate the pro-inflammatory cytokines in rheumatoid arthritis

Abstract

IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. Aim of present study is examine the effect of IL-4 on IL-17 production and proinflammatory cytokines and its effect in Rheumatoid Arthritis. In this study, the relationship between IL-4 and IL-17 were higher than other inflammatory factors. The expression of IL-17 and IL-4 as well as IFN-? and IL-13 in sera of the paitents was measured by QRT-PCR and ELISA. The result of QRT-PCR analysis of IL-17 and IL-4 mRNA levels in the monocyte cells showed that IL-17 is increased significantly at the RA monocyte (p<0.01). Our Conclusion is that IL-4 can be involved in the production of IL-17 at especially the peak of RA. These results imply that the inhibition of IL-17 may decrease the expression of IL-1? and IL-6 production which will result in the aggravation of arthritis. é 2014 AENSI Publisher All rights reserved.