Formulation and prepration of cefuroxime axetil tablets by direct compression

Abstract

Objectives: Cefuroxime axetil is a broad-spectrum second- generation cephalosporin which has activity against gram-positive and gram-negative microorganisms. The aim of the present study is designing and formulation of cefuroxime axetil tablets (250 mg) using direct compressiontechnique which is nowadays considered as a cost effective and simple method of tablet manufacturing. Methods: In order to obtain the optimized products, different formulations were designed using Cefuroxime axetil and 6 different excipients (lactose, avicel, aerosol, PVP, croscarmellose sodium (Ac-Di-Sol) and Magnesium stearate). After measuring the powder flow rate and hardness of formulation, five formulations were selected for dissolution test. Results: All the selected formulations having accepted flow and hardness, released more than 60% drug in 30 minutes. Conclusion: It is concluded that using appropriate statistical methods and direct compression, suitable formulations of Cefuroxime axetil could be reached.