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dc.contributor.authorNosrati, H
dc.contributor.authorAbbasi, R
dc.contributor.authorCharmi, J
dc.contributor.authorRakhshbahar, A
dc.contributor.authorAliakbarzadeh, F
dc.contributor.authorDanafar, H
dc.contributor.authorDavaran, S
dc.date.accessioned2018-08-26T08:55:38Z
dc.date.available2018-08-26T08:55:38Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54331
dc.description.abstractThis work described a folic acid conjugated delivery of chrysin-loaded bovine serum albumin nanoparticles, which could overcome the nonspecific targeting disadvantage. Chrysin (5, 7-dihydroxyflavone) is a natural flavonoid which have some significant biological effects on the processes of chemical defense. Chrysin loaded bovine serum albumin nanoparticles (Chrysin-BSA NPs) were synthesized by a simple desolvation procedure. Afterward, folic acid (FA) was conjugated to the surface of Chrysin-BSA NPs by carbodiimide chemistry (Chrysin-BSA-FA NPs). The resultant Chrysin-BSA-FA NPs showed a spherical shape, with a hydrodynamic diameter of 97.5 آ± 5.8 nm (mean آ± SD) nm and a ?-potential of ?11.3 mV. The in vitro drug release study of chrysin presented a sustained and controlled release pattern. Hemolysis assay and cytotoxicity study results on HFF-2 cell line show that as prepared BSA NPs are biocompatible. Both the Chrysin-BSA NPs and Chrysin-BSA-FA NPs prompted an enhanced cancer cell cytotoxic effect in contrast to chrysin solution. These data recommended that the folate-modified chrysin -loaded vehicle, which demonstrated better biocompatibility and potential superiority, could be a suitable cancer therapy in targeting tumors in the future. é 2018 Elsevier B.V.
dc.language.isoEnglish
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.subjectbovine serum albumin
dc.subjectchrysin
dc.subjectfolate receptor
dc.subjectfolic acid
dc.subjectnanoparticle
dc.subjectantineoplastic activity
dc.subjectArticle
dc.subjectbiocompatibility
dc.subjectbreast cancer
dc.subjectcancer cell
dc.subjectcontrolled study
dc.subjectcytotoxicity assay
dc.subjectdrug conjugation
dc.subjectdrug cytotoxicity
dc.subjectdrug delivery system
dc.subjectdrug formulation
dc.subjecthemolysis assay
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthydrodynamics
dc.subjectin vitro study
dc.subjectMCF-7 cell line
dc.subjectnanoencapsulation
dc.subjectparticle size
dc.subjectsustained drug release
dc.subjectzeta potential
dc.titleFolic acid conjugated bovine serum albumin: An efficient smart and tumor targeted biomacromolecule for inhibition folate receptor positive cancer cells
dc.typeArticle
dc.citation.volume117
dc.citation.spage1125
dc.citation.epage1132
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.ijbiomac.2018.06.026


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